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Klymollins T-X, bioactive eunicellin-based diterpenoids from the soft coral Klyxum molle.

ABSTRACT: Five new eunicellin-based diterpenoids, klymollins T-X (1-5), along with two known compounds (6 and 7) have been isolated from the soft coral Klyxum molle. The structures of these new metabolites were elucidated by extensive spectroscopic analysis and by comparison with related known compounds. Compound 5 was found to exert significant in vitro anti-inflammatory activity against LPS-stimulated RAW264.7 macrophage cells. Furthermore, compounds 4 and 7 were shown to exhibit cytotoxicity against a limited panel of human cancer cell lines.

SUBMITTER: Chang FY

PROVIDER: S-EPMC4052331 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature

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Klymollins T-X, bioactive eunicellin-based diterpenoids from the soft coral Klyxum molle.

Chang Fang-Yu FY Hsu Fang-Jung FJ Tai Chi-Jen CJ Wei Wen-Chi WC Yang Ning-Sun NS Sheu Jyh-Horng JH

Marine drugs 20140522 5

Five new eunicellin-based diterpenoids, klymollins T-X (1-5), along with two known compounds (6 and 7) have been isolated from the soft coral Klyxum molle. The structures of these new metabolites were elucidated by extensive spectroscopic analysis and by comparison with related known compounds. Compound 5 was found to exert significant in vitro anti-inflammatory activity against LPS-stimulated RAW264.7 macrophage cells. Furthermore, compounds 4 and 7 were shown to exhibit cytotoxicity against a ...[more]

PMID: 24857963

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