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Eunicellin-based diterpenoids, hirsutalins N-R, from the formosan soft coral Cladiella hirsuta.

ABSTRACT: New eunicellin-type hirsutalins N-R (1-5), along with two known eunicellins, (6 and 7) were isolated from the soft coral Cladiella hirsuta. The structures of the metabolites were determined by extensive spectroscopic analysis. Cytotoxic activity of compounds 1-7 against the proliferation of a limited panel of cancer cell lines was measured. The in vitro anti-inflammatory activity of compounds 1-7 was evaluated by measuring their ability in suppressing superoxide anion generation and elastase release in fMLP/CB-induced human neutrophils.

SUBMITTER: Huang TZ

PROVIDER: S-EPMC4052299 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature

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Eunicellin-based diterpenoids, hirsutalins N-R, from the formosan soft coral Cladiella hirsuta.

Huang Tzu-Zin TZ Chen Bo-Wei BW Huang Chiung-Yao CY Hwang Tsong-Long TL Dai Chang-Feng CF Sheu Jyh-Horng JH

Marine drugs 20140430 5

New eunicellin-type hirsutalins N-R (1-5), along with two known eunicellins, (6 and 7) were isolated from the soft coral Cladiella hirsuta. The structures of the metabolites were determined by extensive spectroscopic analysis. Cytotoxic activity of compounds 1-7 against the proliferation of a limited panel of cancer cell lines was measured. The in vitro anti-inflammatory activity of compounds 1-7 was evaluated by measuring their ability in suppressing superoxide anion generation and elastase rel ...[more]

PMID: 24796303

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