Ontology highlight
ABSTRACT:
SUBMITTER: Shchepin RV
PROVIDER: S-EPMC4063326 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Shchepin Roman V RV Coffey Aaron M AM Waddell Kevin W KW Chekmenev Eduard Y EY
Analytical chemistry 20140416 12
The synthetic protocol for preparation of 1-(13)C-phosphoenolpyruvate-d2, precursor for parahydrogen-induced polarization (PHIP) of 1-(13)C-phospholactate-d2, is reported. (13)C nuclear spin polarization of 1-(13)C-phospholactate-d2 was increased by >30,000,000-fold (5.75 mT) in water. The reported (13)C polarization level approaching unity (>15.6%), long lifetime of (13)C hyperpolarized 1-(13)C-phospholactate-d2 (58 ± 4 s versus 36 ± 2 s for nondeuterated form at 47.5 mT), and large production ...[more]