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Production of Pure Aqueous 13 C-Hyperpolarized Acetate by Heterogeneous Parahydrogen-Induced Polarization.

ABSTRACT: A supported metal catalyst was designed, characterized, and tested for aqueous phase heterogeneous hydrogenation of vinyl acetate with parahydrogen to produce 13 C-hyperpolarized ethyl acetate for potential biomedical applications. The Rh/TiO2 catalyst with a metal loading of 23.2?wt?% produced strongly hyperpolarized 13 C-enriched ethyl acetate-1-13 C detected at 9.4 T. An approximately 14-fold 13 C signal enhancement was detected using circa 50?% parahydrogen gas without taking into account relaxation losses before and after polarization transfer by magnetic field cycling from nascent parahydrogen-derived protons to 13 C nuclei. This first observation of 13 C PHIP-hyperpolarized products over a supported metal catalyst in an aqueous medium opens up new possibilities for production of catalyst-free aqueous solutions of nontoxic hyperpolarized contrast agents for a wide range of biomolecules amenable to the parahydrogen induced polarization by side arm hydrogenation (PHIP-SAH) approach.

SUBMITTER: Kovtunov KV 

PROVIDER: S-EPMC5544125 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature

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Production of Pure Aqueous <sup>13</sup> C-Hyperpolarized Acetate by Heterogeneous Parahydrogen-Induced Polarization.

Kovtunov Kirill V KV   Barskiy Danila A DA   Shchepin Roman V RV   Salnikov Oleg G OG   Prosvirin Igor P IP   Bukhtiyarov Andrey V AV   Kovtunova Larisa M LM   Bukhtiyarov Valerii I VI   Koptyug Igor V IV   Chekmenev Eduard Y EY  

Chemistry (Weinheim an der Bergstrasse, Germany) 20161010 46

A supported metal catalyst was designed, characterized, and tested for aqueous phase heterogeneous hydrogenation of vinyl acetate with parahydrogen to produce <sup>13</sup> C-hyperpolarized ethyl acetate for potential biomedical applications. The Rh/TiO<sub>2</sub> catalyst with a metal loading of 23.2 wt % produced strongly hyperpolarized <sup>13</sup> C-enriched ethyl acetate-1-<sup>13</sup> C detected at 9.4 T. An approximately 14-fold <sup>13</sup> C signal enhancement was detected using cir  ...[more]

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