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Aqueous, Heterogeneous Parahydrogen-Induced 15N Polarization.

ABSTRACT: The successful transfer of parahydrogen-induced polarization to 15N spins using heterogeneous catalysts in aqueous solutions was demonstrated. Hydrogenation of a synthesized unsaturated 15N-labeled precursor (neurine) with parahydrogen (p-H2) over Rh/TiO2 heterogeneous catalysts yielded a hyperpolarized structural analog of choline. As a result, 15N polarization enhancements of over two orders of magnitude were achieved for the 15N-ethyl trimethyl ammonium ion product in deuterated water at elevated temperatures. Enhanced 15N NMR spectra were successfully acquired at 9.4 T and 0.05 T. Importantly, long hyperpolarization lifetimes were observed at 9.4 T, with a 15N T1 of ~6 min for the product molecules, and the T1 of the deuterated form exceeded 8 min. Taken together, these results show that this approach for generating hyperpolarized species with extended lifetimes in aqueous, biologically compatible solutions is promising for various biomedical applications.

SUBMITTER: Bales LB 

PROVIDER: S-EPMC5723423 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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Aqueous, Heterogeneous Parahydrogen-Induced <sup>15</sup>N Polarization.

Bales Liana B LB   Kovtunov Kirill V KV   Barskiy Danila A DA   Shchepin Roman V RV   Coffey Aaron M AM   Kovtunova Larisa M LM   Bukhtiyarov Andrey V AV   Feldman Matthew A MA   Bukhtiyarov Valerii I VI   Chekmenev Eduard Y EY   Koptyug Igor V IV   Goodson Boyd M BM  

The journal of physical chemistry. C, Nanomaterials and interfaces 20170621 28

The successful transfer of parahydrogen-induced polarization to <sup>15</sup>N spins using heterogeneous catalysts in aqueous solutions was demonstrated. Hydrogenation of a synthesized unsaturated <sup>15</sup>N-labeled precursor (neurine) with parahydrogen (p-H<sub>2</sub>) over Rh/TiO<sub>2</sub> heterogeneous catalysts yielded a hyperpolarized structural analog of choline. As a result, <sup>15</sup>N polarization enhancements of over two orders of magnitude were achieved for the <sup>15</sup>  ...[more]

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