Ischemic memory imaging in nonhuman primates with echocardiographic molecular imaging of selectin expression.

ABSTRACT:

Background

Selectins are adhesion molecules that are expressed by the vascular endothelium upon activation and may be an imaging target for detecting myocardial ischemia long after resolution. The aim of this study was to test the hypothesis that molecular imaging of selectins with myocardial contrast echocardiographic (MCE) molecular imaging could be used to detect recent brief ischemia in closed-chest nonhuman primates.

Methods

Myocardial ischemia was produced in anesthetized adult rhesus macaques (n = 6) by percutaneous balloon catheter occlusion of the left anterior descending or circumflex coronary artery for 5 to 10 min. Three separate macaques served as nonischemic controls. MCE perfusion imaging was performed during coronary occlusion to measure risk area and at 100

SUBMITTER: Davidson BP 

PROVIDER: S-EPMC4065817 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature