Ontology highlight
ABSTRACT:
SUBMITTER: Tiberi M
PROVIDER: S-EPMC4068444 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Tiberi Marika M Tintori Cristina C Ceresola Elisa Rita ER Fazi Roberta R Zamperini Claudio C Calandro Pierpaolo P Franchi Luigi L Selvaraj Manikandan M Botta Lorenzo L Sampaolo Michela M Saita Diego D Ferrarese Roberto R Clementi Massimo M Canducci Filippo F Botta Maurizio M
Antimicrobial agents and chemotherapy 20140310 6
We report here the synthesis of 2-aminothiazolones along with their biological properties as novel anti-HIV agents. Such compounds have proven to act through the inhibition of the gp120-CD4 protein-protein interaction that occurs at the very early stage of the HIV-1 entry process. No cytotoxicity was found for these compounds, and broad antiviral activities against laboratory strains and pseudotyped viruses were documented. Docking simulations have also been applied to predict the mechanism, at ...[more]