Ontology highlight
ABSTRACT:
SUBMITTER: Stratoulias V
PROVIDER: S-EPMC4071072 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Stratoulias Vassilis V Heino Tapio I TI Michon Frederic F
PloS one 20140625 6
Understanding the control of stem cell (SC) differentiation is important to comprehend developmental processes as well as to develop clinical applications. Lin28 is a conserved molecule that is involved in SC maintenance and differentiation by regulating let-7 miRNA maturation. However, little is known about the in vivo function of Lin28. Here, we report critical roles for lin-28 during oogenesis. We found that let-7 maturation was increased in lin-28 null mutant fly ovaries. We showed that lin- ...[more]