Ontology highlight
ABSTRACT:
SUBMITTER: Mozaffari-Jovin S
PROVIDER: S-EPMC4075514 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
RNA biology 20140305 4
For each round of pre-mRNA splicing, a spliceosome is assembled anew on its substrate. RNA-protein remodeling events required for spliceosome assembly, splicing catalysis, and spliceosome disassembly are driven and controlled by a conserved group of ATPases/RNA helicases. The activities of most of these enzymes are timed by their recruitment to the spliceosome. The Brr2 enzyme, however, which mediates spliceosome catalytic activation, is a stable subunit of the spliceosome, and thus, requires sp ...[more]