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Relationship between obesity and the risk of clinically significant depression: Mendelian randomisation study.


ABSTRACT: Obesity has been shown to be associated with depression and it has been suggested that higher body mass index (BMI) increases the risk of depression and other common mental disorders. However, the causal relationship remains unclear and Mendelian randomisation, a form of instrumental variable analysis, has recently been employed to attempt to resolve this issue.To investigate whether higher BMI increases the risk of major depression.Two instrumental variable analyses were conducted to test the causal relationship between obesity and major depression in RADIANT, a large case-control study of major depression. We used a single nucleotide polymorphism (SNP) in FTO and a genetic risk score (GRS) based on 32 SNPs with well-established associations with BMI.Linear regression analysis, as expected, showed that individuals carrying more risk alleles of FTO or having higher score of GRS had a higher BMI. Probit regression suggested that higher BMI is associated with increased risk of major depression. However, our two instrumental variable analyses did not support a causal relationship between higher BMI and major depression (FTO genotype: coefficient -0.03, 95% CI -0.18 to 0.13, P = 0.73; GRS: coefficient -0.02, 95% CI -0.11 to 0.07, P = 0.62).Our instrumental variable analyses did not support a causal relationship between higher BMI and major depression. The positive associations of higher BMI with major depression in probit regression analyses might be explained by reverse causality and/or residual confounding.

SUBMITTER: Hung CF 

PROVIDER: S-EPMC4076654 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature

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Relationship between obesity and the risk of clinically significant depression: Mendelian randomisation study.

Hung Chi-Fa CF   Rivera Margarita M   Craddock Nick N   Owen Michael J MJ   Gill Michael M   Korszun Ania A   Maier Wolfgang W   Mors Ole O   Preisig Martin M   Rice John P JP   Rietschel Marcella M   Jones Lisa L   Middleton Lefkos L   Aitchison Kathy J KJ   Davis Oliver S P OS   Breen Gerome G   Lewis Cathryn C   Farmer Anne A   McGuffin Peter P  

The British journal of psychiatry : the journal of mental science 20140508 1


<h4>Background</h4>Obesity has been shown to be associated with depression and it has been suggested that higher body mass index (BMI) increases the risk of depression and other common mental disorders. However, the causal relationship remains unclear and Mendelian randomisation, a form of instrumental variable analysis, has recently been employed to attempt to resolve this issue.<h4>Aims</h4>To investigate whether higher BMI increases the risk of major depression.<h4>Method</h4>Two instrumental  ...[more]

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