Ontology highlight
ABSTRACT:
SUBMITTER: Deak AT
PROVIDER: S-EPMC4077590 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Deak Andras T AT Blass Sandra S Khan Muhammad J MJ Groschner Lukas N LN Waldeck-Weiermair Markus M Hallström Seth S Graier Wolfgang F WF Malli Roland R
Journal of cell science 20140507 Pt 13
Mitochondria contribute to cell signaling by controlling store-operated Ca(2+) entry (SOCE). SOCE is activated by Ca(2+) release from the endoplasmic reticulum (ER), whereupon stromal interacting molecule 1 (STIM1) forms oligomers, redistributes to ER-plasma-membrane junctions and opens plasma membrane Ca(2+) channels. The mechanisms by which mitochondria interfere with the complex process of SOCE are insufficiently clarified. In this study, we used an shRNA approach to investigate the direct in ...[more]