Ontology highlight
ABSTRACT:
SUBMITTER: Wang G
PROVIDER: S-EPMC407824 | biostudies-literature | 2004
REPOSITORIES: biostudies-literature
Wang Gan G Chuang Lynn L Zhang Xiaohong X Colton Stephanie S Dombkowski Alan A Reiners John J Diakiw Amy A Xu Xiaoxin Susan XS
Nucleic acids research 20040423 7
XPC is an important DNA damage recognition protein involved in DNA nucleotide excision repair. We have studied the role of the XPC protein in cisplatin treatment-mediated cell cycle regulation. Through the comparison of microarray data obtained from human normal fibroblasts and two individual XPC-defective cell lines, 486 genes were identified as XPC-responsive genes in the cisplatin treatment (with a minimal 1.5-fold change) and 297 of these genes were further mapped to biological pathways and ...[more]