Ontology highlight
ABSTRACT:
SUBMITTER: Deborde S
PROVIDER: S-EPMC4078870 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Deborde Sylvie S Perret Emilie E Gravotta Diego D Deora Ami A Salvarezza Susana S Schreiner Ryan R Rodriguez-Boulan Enrique E
Nature 20080401 7188
Clathrin-coated vesicles are vehicles for intracellular trafficking in all nucleated cells, from yeasts to humans. Many studies have demonstrated their essential roles in endocytosis and cellular signalling processes at the plasma membrane. By contrast, very few of their non-endocytic trafficking roles are known, the best characterized being the transport of hydrolases from the Golgi complex to the lysosome. Here we show that clathrin is required for polarity of the basolateral plasma membrane p ...[more]