Ontology highlight
ABSTRACT:
SUBMITTER: Wang P
PROVIDER: S-EPMC4080428 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20131201 6164
Erythropoietin is a signaling glycoprotein that controls the fundamental process of erythropoiesis, orchestrating the production and maintenance of red blood cells. As administrated clinically, erythropoietin has a polypeptide backbone with complex dishomogeneity in its carbohydrate domains. Here we describe the total synthesis of homogeneous erythropoietin with consensus carbohydrate domains incorporated at all of the native glycosylation sites. The oligosaccharide sectors were built by total s ...[more]