Ontology highlight
ABSTRACT:
SUBMITTER: Daubner GM
PROVIDER: S-EPMC4081071 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Daubner Gerrit M GM Brümmer Anneke A Tocchini Cristina C Gerhardy Stefan S Ciosk Rafal R Zavolan Mihaela M Allain Frédéric H-T FH
Nucleic acids research 20140516 12
The STAR family comprises ribonucleic acid (RNA)-binding proteins that play key roles in RNA-regulatory processes. RNA recognition is achieved by a KH domain with an additional α-helix (QUA2) that seems to extend the RNA-binding surface to six nucleotides for SF1 (Homo sapiens) and seven nucleotides for GLD-1 (Caenorhabditis elegans). To understand the structural basis of this probable difference in specificity, we determined the solution structure of GLD-1 KH-QUA2 with the complete consensus se ...[more]