Ontology highlight
ABSTRACT:
SUBMITTER: Alcolea MP
PROVIDER: S-EPMC4085550 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Alcolea Maria P MP Greulich Philip P Wabik Agnieszka A Frede Julia J Simons Benjamin D BD Jones Philip H PH
Nature cell biology 20140511 6
Multiple cancers may arise from within a clonal region of preneoplastic epithelium, a phenomenon termed 'field change'. However, it is not known how field change develops. Here we investigate this question using lineage tracing to track the behaviour of scattered single oesophageal epithelial progenitor cells expressing a mutation that inhibits the Notch signalling pathway. Notch is frequently subject to inactivating mutation in squamous cancers. Quantitative analysis reveals that cell divisions ...[more]