Ontology highlight
ABSTRACT:
SUBMITTER: Simino J
PROVIDER: S-EPMC4085636 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Simino Jeannette J Shi Gang G Bis Joshua C JC Chasman Daniel I DI Ehret Georg B GB Gu Xiangjun X Guo Xiuqing X Hwang Shih-Jen SJ Sijbrands Eric E Smith Albert V AV Verwoert Germaine C GC Bragg-Gresham Jennifer L JL Cadby Gemma G Chen Peng P Cheng Ching-Yu CY Corre Tanguy T de Boer Rudolf A RA Goel Anuj A Johnson Toby T Khor Chiea-Chuen CC Lluís-Ganella Carla C Luan Jian'an J Lyytikäinen Leo-Pekka LP Nolte Ilja M IM Sim Xueling X Sõber Siim S van der Most Peter J PJ Verweij Niek N Zhao Jing Hua JH Amin Najaf N Boerwinkle Eric E Bouchard Claude C Dehghan Abbas A Eiriksdottir Gudny G Elosua Roberto R Franco Oscar H OH Gieger Christian C Harris Tamara B TB Hercberg Serge S Hofman Albert A James Alan L AL Johnson Andrew D AD Kähönen Mika M Khaw Kay-Tee KT Kutalik Zoltan Z Larson Martin G MG Launer Lenore J LJ Li Guo G Liu Jianjun J Liu Kiang K Morrison Alanna C AC Navis Gerjan G Ong Rick Twee-Hee RT Papanicolau George J GJ Penninx Brenda W BW Psaty Bruce M BM Raffel Leslie J LJ Raitakari Olli T OT Rice Kenneth K Rivadeneira Fernando F Rose Lynda M LM Sanna Serena S Scott Robert A RA Siscovick David S DS Stolk Ronald P RP Uitterlinden Andre G AG Vaidya Dhananjay D van der Klauw Melanie M MM Vasan Ramachandran S RS Vithana Eranga Nishanthie EN Völker Uwe U Völzke Henry H Watkins Hugh H Young Terri L TL Aung Tin T Bochud Murielle M Farrall Martin M Hartman Catharina A CA Laan Maris M Lakatta Edward G EG Lehtimäki Terho T Loos Ruth J F RJ Lucas Gavin G Meneton Pierre P Palmer Lyle J LJ Rettig Rainer R Snieder Harold H Tai E Shyong ES Teo Yik-Ying YY van der Harst Pim P Wareham Nicholas J NJ Wijmenga Cisca C Wong Tien Yin TY Fornage Myriam M Gudnason Vilmundur V Levy Daniel D Palmas Walter W Ridker Paul M PM Rotter Jerome I JI van Duijn Cornelia M CM Witteman Jacqueline C M JC Chakravarti Aravinda A Rao Dabeeru C DC
American journal of human genetics 20140619 1
Although age-dependent effects on blood pressure (BP) have been reported, they have not been systematically investigated in large-scale genome-wide association studies (GWASs). We leveraged the infrastructure of three well-established consortia (CHARGE, GBPgen, and ICBP) and a nonstandard approach (age stratification and metaregression) to conduct a genome-wide search of common variants with age-dependent effects on systolic (SBP), diastolic (DBP), mean arterial (MAP), and pulse (PP) pressure. I ...[more]