Ontology highlight
ABSTRACT:
SUBMITTER: Gfeller D
PROVIDER: S-EPMC4086140 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Gfeller David D Grosdidier Aurélien A Wirth Matthias M Daina Antoine A Michielin Olivier O Zoete Vincent V
Nucleic acids research 20140503 Web Server issue
Bioactive small molecules, such as drugs or metabolites, bind to proteins or other macro-molecular targets to modulate their activity, which in turn results in the observed phenotypic effects. For this reason, mapping the targets of bioactive small molecules is a key step toward unraveling the molecular mechanisms underlying their bioactivity and predicting potential side effects or cross-reactivity. Recently, large datasets of protein-small molecule interactions have become available, providing ...[more]