Ontology highlight
ABSTRACT:
SUBMITTER: Velagapudi SP
PROVIDER: S-EPMC3962094 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Velagapudi Sai Pradeep SP Gallo Steven M SM Disney Matthew D MD
Nature chemical biology 20140209 4
Oligonucleotides are designed to target RNA using base pairing rules, but they can be hampered by poor cellular delivery and nonspecific stimulation of the immune system. Small molecules are preferred as lead drugs or probes but cannot be designed from sequence. Herein, we describe an approach termed Inforna that designs lead small molecules for RNA from solely sequence. Inforna was applied to all human microRNA hairpin precursors, and it identified bioactive small molecules that inhibit biogene ...[more]