Ontology highlight
ABSTRACT:
SUBMITTER: Wong W
PROVIDER: S-EPMC4086275 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
eLife 20140609
Malaria inflicts an enormous burden on global human health. The emergence of parasite resistance to front-line drugs has prompted a renewed focus on the repositioning of clinically approved drugs as potential anti-malarial therapies. Antibiotics that inhibit protein translation are promising candidates for repositioning. We have solved the cryo-EM structure of the cytoplasmic ribosome from the human malaria parasite, Plasmodium falciparum, in complex with emetine at 3.2 Å resolution. Emetine is ...[more]