Ontology highlight
ABSTRACT:
SUBMITTER: Sjors SHW Scheres
PROVIDER: EMPIAR-10028 | biostudies-other |
REPOSITORIES: biostudies-other
Wong Wilson W Bai Xiao-chen XC Brown Alan A Fernandez Israel S IS Hanssen Eric E Condron Melanie M Tan Yan Hong YH Baum Jake J Scheres Sjors H W SH
eLife 20140609
Malaria inflicts an enormous burden on global human health. The emergence of parasite resistance to front-line drugs has prompted a renewed focus on the repositioning of clinically approved drugs as potential anti-malarial therapies. Antibiotics that inhibit protein translation are promising candidates for repositioning. We have solved the cryo-EM structure of the cytoplasmic ribosome from the human malaria parasite, Plasmodium falciparum, in complex with emetine at 3.2 Å resolution. Emetine is ...[more]