Ontology highlight
ABSTRACT:
SUBMITTER: Ponomareva OY
PROVIDER: S-EPMC4087204 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Ponomareva Olga Y OY Holmen Ian C IC Sperry Aiden J AJ Eliceiri Kevin W KW Halloran Mary C MC
The Journal of neuroscience : the official journal of the Society for Neuroscience 20140701 28
Precise regulation of axon branching is crucial for neuronal circuit formation, yet the mechanisms that control branch formation are not well understood. Moreover, the highly complex morphology of neurons makes them critically dependent on protein/membrane trafficking and transport systems, although the functions for membrane trafficking in neuronal morphogenesis are largely undefined. Here we identify a kinesin adaptor, Calsyntenin-1 (Clstn-1), as an essential regulator of axon branching and ne ...[more]