Ontology highlight
ABSTRACT:
SUBMITTER: Sluis-Cremer N
PROVIDER: S-EPMC4089891 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Sluis-Cremer Nicolas N Jordan Michael R MR Huber Kelly K Wallis Carole L CL Bertagnolio Silvia S Mellors John W JW Parkin Neil T NT Harrigan P Richard PR
Antiviral research 20140416
The nonnucleoside reverse transcriptase (RT) inhibitor rilpivirine (RPV) has been co-formulated with emtricitabine and tenofovir disoproxil fumarate for initial therapy of HIV-1-infected individuals. RPV, formulated as a long-acting nanosuspension, will also be assessed for its ability to prevent HIV-1 infection in resource limited settings. In this study, we determined whether any pre-existing genetic differences occurred among different HIV-1 subtypes at residues in RT associated with decrease ...[more]