Ontology highlight
ABSTRACT:
SUBMITTER: O'Connell JD
PROVIDER: S-EPMC4089986 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
O'Connell Jeremy D JD Zhao Alice A Ellington Andrew D AD Marcotte Edward M EM
Annual review of cell and developmental biology 20120101
Both focused and large-scale cell biological and biochemical studies have revealed that hundreds of metabolic enzymes across diverse organisms form large intracellular bodies. These proteinaceous bodies range in form from fibers and intracellular foci--such as those formed by enzymes of nitrogen and carbon utilization and of nucleotide biosynthesis--to high-density packings inside bacterial microcompartments and eukaryotic microbodies. Although many enzymes clearly form functional mega-assemblie ...[more]