Ontology highlight
ABSTRACT:
SUBMITTER: Pryshchep S
PROVIDER: S-EPMC4090054 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Pryshchep Sergey S Zarnitsyna Veronika I VI Hong Jinsung J Evavold Brian D BD Zhu Cheng C
Journal of immunology (Baltimore, Md. : 1950) 20140602 1
T cell activation by Ag is one of the key events in adaptive immunity. It is triggered by interactions of the TCR and coreceptor (CD8 or CD4) with antigenic peptides embedded in MHC (pMHC) molecules expressed on APCs. The mechanism of how signal is initiated remains unclear. In this article, we complement our two-dimensional kinetic analysis of TCR-pMHC-CD8 interaction with concurrent calcium imaging to examine how ligand engagement of TCR with and without the coengagement of CD8 initiates signa ...[more]