Ontology highlight
ABSTRACT:
SUBMITTER: Schilcher K
PROVIDER: S-EPMC4091580 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
The Journal of infectious diseases 20140212 3
The Gram-positive human pathogen Staphylococcus aureus causes a variety of human diseases such as skin infections, pneumonia, and endocarditis. The micrococcal nuclease Nuc1 is one of the major S. aureus virulence factors and allows the bacterium to avoid neutrophil extracellular trap (NET)-mediated killing. We found that addition of the protein synthesis inhibitor clindamycin to S. aureus LAC cultures decreased nuc1 transcription and subsequently blunted nuclease activity in a molecular beacon- ...[more]