Ontology highlight
ABSTRACT:
SUBMITTER: Eisenbeis J
PROVIDER: S-EPMC6047304 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Frontiers in cellular and infection microbiology 20180709
The extracellular adherence protein (Eap) of <i>Staphylococcus aureus</i> is a secreted protein known to exert a number of adhesive and immunomodulatory properties. Here we describe the intrinsic DNA binding activity of this multifunctional secretory factor. By using atomic force microscopy, we provide evidence that Eap can bind and aggregate DNA. While the origin of the DNA substrate (e.g., eukaryotic, bacterial, phage, and artificial DNA) seems to not be of major importance, the DNA structure ...[more]