Ontology highlight
ABSTRACT:
SUBMITTER: Vieira DF
PROVIDER: S-EPMC4091728 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Chembiochem : a European journal of chemical biology 20140425 8
Chagas disease is a chronic infection caused by the protozoan parasite Trypanosoma cruzi, manifested in progressive cardiomyopathy and/or gastrointestinal dysfunction. Therapeutic options to prevent or treat Chagas disease are limited. CYP51, the enzyme key to the biosynthesis of eukaryotic membrane sterols, is a validated drug target in both fungi and T. cruzi. Sulfonamide derivatives of 4-aminopyridyl-based inhibitors of T. cruzi CYP51 (TcCYP51), including the sub-nanomolar compound 3, have mo ...[more]