Ontology highlight
ABSTRACT:
SUBMITTER: Vieira DF
PROVIDER: S-EPMC4266343 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20141125 23
Chagas disease is a chronic infection in humans caused by Trypanosoma cruzi and manifested in progressive cardiomyopathy and/or gastrointestinal dysfunction. Limited therapeutic options to prevent and treat Chagas disease put 8 million people infected with T. cruzi worldwide at risk. CYP51, involved in the biosynthesis of the membrane sterol component in eukaryotes, is a promising drug target in T. cruzi. We report the structure-activity relationships (SAR) of an N-arylpiperazine series of N-ind ...[more]