Ontology highlight
ABSTRACT:
SUBMITTER: Calvet CM
PROVIDER: S-EPMC4148169 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20140819 16
CYP51 is a P450 enzyme involved in the biosynthesis of the sterol components of eukaryotic cell membranes. CYP51 inhibitors have been developed to treat infections caused by fungi, and more recently the protozoan parasite Trypanosoma cruzi, the causative agent of Chagas disease. To specifically optimize drug candidates for T. cruzi CYP51 (TcCYP51), we explored the structure-activity relationship (SAR) of a N-indolyl-oxopyridinyl-4-aminopropanyl-based scaffold originally identified in a target-ba ...[more]