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Repurposing Drugs in Oncology (ReDO)-mebendazole as an anti-cancer agent.

ABSTRACT: Mebendazole, a well-known anti-helminthic drug in wide clinical use, has anti-cancer properties that have been elucidated in a broad range of pre-clinical studies across a number of different cancer types. Significantly, there are also two case reports of anti-cancer activity in humans. The data are summarised and discussed in relation to suggested mechanisms of action. Based on the evidence presented, it is proposed that mebendazole would synergise with a range of other drugs, including existing chemotherapeutics, and that further exploration of the potential of mebendazole as an anti-cancer therapeutic is warranted. A number of possible combinations with other drugs are discussed in the Appendix.

SUBMITTER: Pantziarka P

PROVIDER: S-EPMC4096024 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Repurposing Drugs in Oncology (ReDO)-mebendazole as an anti-cancer agent.

Pantziarka Pan P Bouche Gauthier G Meheus Lydie L Sukhatme Vidula V Sukhatme Vikas P VP

Ecancermedicalscience 20140710

Mebendazole, a well-known anti-helminthic drug in wide clinical use, has anti-cancer properties that have been elucidated in a broad range of pre-clinical studies across a number of different cancer types. Significantly, there are also two case reports of anti-cancer activity in humans. The data are summarised and discussed in relation to suggested mechanisms of action. Based on the evidence presented, it is proposed that mebendazole would synergise with a range of other drugs, including existin ...[more]

PMID: 25075217

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