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Lack of association between a functional polymorphism (rs1800796) in the interleukin-6 gene promoter and lung cancer.

ABSTRACT: BACKGROUND: A number of studies have examined the association between interleukin-6 (IL-6) rs1800796 polymorphism and risk of lung cancer but revealed inconsistent results. The aim of this study was to clarify the association between IL-6 rs1800796 polymorphism and risk of lung cancer. METHODS: Literature databases including PubMed, Embase and CNKI were searched up to January 2014. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) under co-dominant model, dominant model and recessive model were estimated using random-effects model. RESULTS: A total of seven studies, including 2691 lung cancer cases and 3067 controls, were included in the meta-analysis. The results suggested that IL-6 rs1800796 polymorphism was not associated with risk of lung cancer under homogeneous co-dominant model (OR?=?1.06, 95%CI?=?0.73-1.54), heterogeneous co-dominant model (OR?=?1.24, 95%CI?=?0.96-1.60), dominant model (OR?=?1.23, 95%CI?=?0.95-1.58) and recessive model (OR?=?0.96, 95%CI?=?0.70-1.32). The association was still not significant in either never-smokers (OR?=?1.19, 95%CI?=?0.95-1.48) or ever-smokers (OR?=?1.73, 95%CI?=?0.89-3.36). CONCLUSION: The present meta-analysis suggested that there was no association between IL-6 rs1800796 polymorphism and lung cancer, which was independent of smoking status. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1060061508127855.

SUBMITTER: Wang W

PROVIDER: S-EPMC4100037 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Lack of association between a functional polymorphism (rs1800796) in the interleukin-6 gene promoter and lung cancer.

Wang Weihua W Chen Jie J Zhao Feng F Zhang Burong B Yu Hongsheng H

Diagnostic pathology 20140701

<h4>Background</h4>A number of studies have examined the association between interleukin-6 (IL-6) rs1800796 polymorphism and risk of lung cancer but revealed inconsistent results. The aim of this study was to clarify the association between IL-6 rs1800796 polymorphism and risk of lung cancer.<h4>Methods</h4>Literature databases including PubMed, Embase and CNKI were searched up to January 2014. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) under co-dominant model, dominant mod ...[more]

PMID: 24984610

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Project description:ObjectiveThe results of published studies which examined the association between variable number tandem repeat (VNTR) polymorphism of interleukin-1 receptor antagonist (IL-1RN) and ischemic stroke (IS) are conflicting. Thus, we performed a meta-analysis to examine the potential association between IL-1RN VNTR polymorphism and IS risk.MethodsA systematic literature search of PubMed, Embase, Medline, Web of Science, Cochrane Library, Chinese Biomedical Literature Database, Chinese National Knowledge Infrastructure, CQVIP, and WANFANG Database identified 10 studies with 2331 cases and 3335 controls. The pooled odds ratio (OR) with 95% confidence interval (95% CI) was calculated to evaluate the strength of the association. Subgroup analysis and meta-regression analysis were used to investigate the potential sources of heterogeneity. Begg funnel plots were used to explore the publication bias.ResultsIn this study, no enough proof was found to prove the association between IL-1RN 86-bp VNTR polymorphism and IS risk with random-effects model in the homozygous model (1/1 vs 2/2, OR = 0.97, 95% CI = 0.50-1.87, Pheterogeneity = .00), the heterozygous model (1/2 vs 2/2, OR = 0.64, 95% CI = 0.41-1.01, Pheterogeneity = .10), the dominant model (1/1 + 1/2 vs 2/2, OR = 0.85, 95% CI = 0.51-1.42, Pheterogeneity = .02), the recessive model (1/1 vs 1/2 + 2/2, OR = 0.69, 95% CI = 0.46-1.03, Pheterogeneity = .00), and allelic model (1 vs 2, OR = 1.24, 95% CI = 0.89-1.74, Pheterogeneity = .00). A marginally significant negative association was observed between IL-1RN 86-bp VNTR polymorphism and IS risk in the heterozygous model in the fixed-effects model (1/2 vs 2/2, OR = 0.71, 95% CI = 0.53-0.95, Pheterogeneity = .10). In subgroup analyses, similar association was found in the group whose control size was lower than 300.ConclusionIn conclusion, our results suggested that there was no sufficient evidence to support the association between IL-1RN 86-bp VNTR polymorphism and IS. Further large epidemiologic studies need to be done to confirm these findings.

Dataset Information

Lack of association between a functional polymorphism (rs1800796) in the interleukin-6 gene promoter and lung cancer.

Publications

Lack of association between a functional polymorphism (rs1800796) in the interleukin-6 gene promoter and lung cancer.

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