Dataset Information

Lack of Association between Interleukin-1? Gene Polymorphism (rs16944) and Chronic Periodontitis: From a Case-Control Studies to an Updated Meta-Analysis.

ABSTRACT: Background:Interleukin-1? (IL-1?) plays an important role as a mediator of various inflammatory responses in chronic periodontitis. Several studies have investigated the potential relationship between IL-1? polymorphism (rs16944) and susceptibility to chronic periodontitis; inflammatory process is involved, but conclusions is still controversial. Objective:The aim of this study was to determine whether the IL-1? polymorphism (rs16944) is associated with susceptibility to chronic periodontitis. Material and Methods:For the case-control study, 51 patients with chronic periodontitis and 33 healthy control patients were recruited in the study. Genotyping was conducted by direct sequencing. SNPStats and SPSS 18.0 were used for the analysis of genetic data and to evaluate odds ratios, 95% confidence intervals, and P values; logistic regression models were used. And to perform meta-analysis, studies about IL-1? polymorphism (rs16944) and chronic periodontitis were searched in PubMed, Embase, Google Scholar, and Korean Studies Information Service System (KISS) electronic databases until July 2017. Results:In our case-control study, no significant relationship was revealed between IL-1? polymorphism (rs16944) and chronic periodontitis (P > 0.05 in each model). When combined with the previous studies in the meta-analysis, the result was not associated with chronic periodontitis in any of the models (CC vs. CT?+?TT: OR?=?0.97, 95% CI?=?0.762-1.246; CC?+?CT vs. TT: OR?=?0.90, 95% CI?=?0.658-1.232; and C vs. T: OR?=?0.93, 95% CI?=?0.774-1.128). The subgroup analysis stratified by ethnicity showed a weak association between the IL-1? polymorphism (rs16944) and chronic periodontitis in the Caucasian population (recessive model, OR?=?1.34, 95% CI?=?1.017-1.758, P = 0.037). Conclusion:Evidences from a case-control study and the meta-analysis suggest that IL-1? polymorphism (rs16944) is not associated with susceptibility to chronic periodontitis.

SUBMITTER: Hong SJ

PROVIDER: S-EPMC6311801 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Lack of Association between Interleukin-1<i>β</i> Gene Polymorphism (rs16944) and Chronic Periodontitis: From a Case-Control Studies to an Updated Meta-Analysis.

Hong Seoung-Jin SJ Kang Sang Wook SW Kang Sang Wook SW Kim Su Kang SK Kim Young Sik YS Ban Ju Yeon JY

Disease markers 20181211

<h4>Background</h4>Interleukin-1<i>β</i> (IL-1<i>β</i>) plays an important role as a mediator of various inflammatory responses in chronic periodontitis. Several studies have investigated the potential relationship between IL-1<i>β</i> polymorphism (rs16944) and susceptibility to chronic periodontitis; inflammatory process is involved, but conclusions is still controversial.<h4>Objective</h4>The aim of this study was to determine whether the IL-1<i>β</i> polymorphism (rs16944) is associated with ...[more]

PMID: 30647799

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Project description:ObjectiveNumerous studies have investigated the associations between herpesviruses and chronic periodontitis; however, the results remain controversial. To derive a more precise estimation, a meta-analysis on all available studies was performed to identify the association between herpesviruses and chronic periodontitis.MethodsA computerized literature search was conducted in December 2014 to identify eligible case-control studies from the PUBMED and EMBASE databases according to inclusion and exclusion criteria. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were used to assess the association between herpesviruses and risk of chronic periodontitis. A fixed or random effects model was determined based on a heterogeneity test. Sensitivity analysis was conducted to investigate stability and reliability. Publication bias was investigated using the Begg rank correlation test and Egger's funnel plot.ResultsTen eligible studies were included to investigate the association between Epstein-Barr virus (EBV) and chronic periodontitis. The results showed that EBV has a significant association with chronic periodontitis compared with periodontally healthy group (OR = 5.74, 95% CI = 2.53-13.00, P<0.001). The association between human cytomegalovirus (HCMV) and chronic periodontitis was analyzed in 10 studies. The pooled result showed that HCMV also has a significant association with chronic periodontitis (OR = 3.59, 95% CI = 1.41-9.16, P = 0.007). Similar results were found in the sensitivity analyses. No significant publication bias was observed. Two eligible studies were included to investigate the association between herpes simplex virus (HSV) and chronic periodontitis risk. The association between HSV and chronic periodontitis was inconclusive (OR = 2.81 95% CI = 0.95-8.27, P = 0.06). Only one included study investigated the association between human herpesvirus 7 (HHV-7) and chronic periodontitis risk (OR = 1.00, 95% CI = 0.21-4.86).ConclusionThe findings of this meta-analysis suggest that two members of the herpesvirus family, EBV and HCMV, are significantly associated with chronic periodontitis. There is insufficient evidence to support associations between HSV, HHV-7 and chronic periodontitis.

Dataset Information

Lack of Association between Interleukin-1? Gene Polymorphism (rs16944) and Chronic Periodontitis: From a Case-Control Studies to an Updated Meta-Analysis.

Publications

Lack of Association between Interleukin-1<i>β</i> Gene Polymorphism (rs16944) and Chronic Periodontitis: From a Case-Control Studies to an Updated Meta-Analysis.

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