Ontology highlight
ABSTRACT:
SUBMITTER: Olivier-Van Stichelen S
PROVIDER: S-EPMC4101651 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Olivier-Van Stichelen Stéphanie S Dehennaut Vanessa V Buzy Armelle A Zachayus Jean-Luc JL Guinez Céline C Mir Anne-Marie AM El Yazidi-Belkoura Ikram I Copin Marie-Christine MC Boureme Didier D Loyaux Denis D Ferrara Pascual P Lefebvre Tony T
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20140417 8
Dysfunctions in Wnt signaling increase β-catenin stability and are associated with cancers, including colorectal cancer. In addition, β-catenin degradation is decreased by nutrient-dependent O-GlcNAcylation. Human colon tumors and colons from mice fed high-carbohydrate diets exhibited higher amounts of β-catenin and O-GlcNAc relative to healthy tissues and mice fed a standard diet, respectively. Administration of the O-GlcNAcase inhibitor thiamet G to mice also increased colonic expression of β- ...[more]