Ontology highlight
ABSTRACT:
SUBMITTER: Carlino MS
PROVIDER: S-EPMC4102942 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Carlino M S MS Haydu L E LE Kakavand H H Menzies A M AM Hamilton A L AL Yu B B Ng C C CC Cooper W A WA Thompson J F JF Kefford R F RF O'Toole S A SA Scolyer R A RA Long G V GV
British journal of cancer 20140610 2
<h4>Background</h4>The prognostic significance of BRAF and NRAS mutations in metastatic melanoma patients remains uncertain, with several studies reporting conflicting results, often biased by the inclusion of patients treated with BRAF and MEK (MAPK) inhibitors. We therefore interrogated a historical cohort of patients free of the confounding influence of MAPK inhibitor therapy.<h4>Methods</h4>Patients with available archival tissue first diagnosed with metastatic melanoma between 2002 and 2006 ...[more]