Rhenium Complexes with Red-Light-Induced Anticancer Activity.
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ABSTRACT:
SUBMITTER: Wahler K
PROVIDER: S-EPMC4103186 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Publications
Rhenium Complexes with Red-Light-Induced Anticancer Activity.
Wähler Kathrin K Ludewig Anja A Szabo Patrick P Harms Klaus K Meggers Eric E
European journal of inorganic chemistry 20140201 5
Rhenium(I) pyridocarbazole complexes with photoinduced antiproliferative activity are reported. The substitutionally inert complexes induce cell death by singlet oxygen generation upon irradiation with red light (<i>λ</i> ≥ 620 nm), while only weak background cytotoxicity is observed in the dark. Due to their ability to inhibit protein kinases (nanomolar IC<sub>50</sub> values against Pim1 at 10 μM ATP), this class of rhenium complexes point into the direction of dual function antiproliferative ...[more]
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