Ontology highlight
ABSTRACT:
SUBMITTER: Tovy A
PROVIDER: S-EPMC5495125 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Tovy Ayala A Spiro Adam A McCarthy Ryan R Shipony Zohar Z Aylon Yael Y Allton Kendra K Ainbinder Elena E Furth Noa N Tanay Amos A Barton Michelle M Oren Moshe M
Genes & development 20170501 10
DNA methylation is a key regulator of embryonic stem cell (ESC) biology, dynamically changing between naïve, primed, and differentiated states. The p53 tumor suppressor is a pivotal guardian of genomic stability, but its contributions to epigenetic regulation and stem cell biology are less explored. We report that, in naïve mouse ESCs (mESCs), p53 restricts the expression of the de novo DNA methyltransferases Dnmt3a and Dnmt3b while up-regulating Tet1 and Tet2, which promote DNA demethylation. T ...[more]