Ontology highlight
ABSTRACT:
SUBMITTER: Sivina M
PROVIDER: S-EPMC4104473 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Sivina Mariela M Kreitman Robert J RJ Arons Evgeny E Ravandi Farhad F Burger Jan A JA
British journal of haematology 20140402 2
B cell receptor (BCR) signalling plays a critical role in the progression of several B-cell malignancies, but its role in hairy cell leukaemia (HCL) is ambiguous. Bruton tyrosine kinase (BTK), a key player in BCR signalling, as well as B cell migration and adhesion, can be targeted with ibrutinib, a selective, irreversible BTK inhibitor. We analysed BTK expression and function in HCL and analysed the effects of ibrutinib on HCL cells. We demonstrated uniform BTK protein expression in HCL cells. ...[more]