Ontology highlight
ABSTRACT:
SUBMITTER: Kocarnik JM
PROVIDER: S-EPMC4104750 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Kocarnik Jonathan M JM Pendergrass Sarah A SA Carty Cara L CL Pankow James S JS Schumacher Fredrick R FR Cheng Iona I Durda Peter P Ambite José Luis JL Deelman Ewa E Cook Nancy R NR Liu Simin S Wactawski-Wende Jean J Hutter Carolyn C Brown-Gentry Kristin K Wilson Sarah S Best Lyle G LG Pankratz Nathan N Hong Ching-Ping CP Cole Shelley A SA Voruganti V Saroja VS Bůžkova Petra P Jorgensen Neal W NW Jenny Nancy S NS Wilkens Lynne R LR Haiman Christopher A CA Kolonel Laurence N LN Lacroix Andrea A North Kari K Jackson Rebecca R Le Marchand Loic L Hindorff Lucia A LA Crawford Dana C DC Gross Myron M Peters Ulrike U
Circulation. Cardiovascular genetics 20140312 2
<h4>Background</h4>C-reactive protein (CRP) is a biomarker of inflammation. Genome-wide association studies (GWAS) have identified single-nucleotide polymorphisms (SNPs) associated with CRP concentrations and inflammation-related traits such as cardiovascular disease, type 2 diabetes mellitus, and obesity. We aimed to replicate previous CRP-SNP associations, assess whether these associations generalize to additional race/ethnicity groups, and evaluate inflammation-related SNPs for a potentially ...[more]