Generation of infectious virus particles from inducible transgenic genomes.
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ABSTRACT:
SUBMITTER: Wernet MF
PROVIDER: S-EPMC4110053 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Publications
Generation of infectious virus particles from inducible transgenic genomes.
Wernet Mathias F MF Klovstad Martha M Clandinin Thomas R TR
Current biology : CB 20140201 3
Arboviruses like dengue virus, yellow fever virus, and West Nile virus are enveloped particles spread by mosquitoes, infecting millions of humans per year, with neither effective vaccines, nor specific antiviral therapies [1,2]. Previous studies of infection and virus replication utilize either purified virus particles or deficient genomes that do not complete the viral life cycle [1,2]. Here we describe transgenic Drosophila strains expressing trans-complementing genomes (referred to as 'replic ...[more]
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