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Three New Humulane Sesquiterpenes from Cultures of the Fungus Antrodiella albocinnamomea.

ABSTRACT: Three new humulane-type sesquiterpenes, antrodols A-C (1-3), were isolated from cultures of the fungus Antrodiella albocinnamomea. Their structures were elucidated on the basis of extensive spectroscopic analysis. Antrodols A-C (1-3) are first examples of humulane-type sesquiterpenes isolated from cultures of higher fungi, and antrodol A (1) was the first report of humulane-type sesquiterpene with a methyl rearranged at C-3. All compounds were evaluated in the enzyme inhibition assay against two protein-tyrosine phosphatases (PTPs): MEG2 and PTP1Bc.

SUBMITTER: Chen ZM

PROVIDER: S-EPMC4111878 | biostudies-literature |

REPOSITORIES: biostudies-literature

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