Branching morphogenesis of immortalized human bronchial epithelial cells in three-dimensional culture.
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ABSTRACT:
SUBMITTER: Kaisani A
PROVIDER: S-EPMC4112006 | biostudies-literature | 2014 Mar-Apr
REPOSITORIES: biostudies-literature
Publications
Branching morphogenesis of immortalized human bronchial epithelial cells in three-dimensional culture.
Kaisani Aadil A Delgado Oliver O Fasciani Gail G Kim Sang Bum SB Wright Woodring E WE Minna John D JD Shay Jerry W JW
Differentiation; research in biological diversity 20140301 3-4
While mouse models have contributed in our understanding of lung development, repair and regeneration, inherent differences between the murine and human airways requires the development of new models using human airway epithelial cells. In this study, we describe a three-dimensional model system using human bronchial epithelial cells (HBECs) cultured on reconstituted basement membrane. HBECs form complex budding and branching structures on reconstituted basement membrane when co-cultured with hu ...[more]
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