Ontology highlight
ABSTRACT:
SUBMITTER: Tien J
PROVIDER: S-EPMC4112547 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Tien Jason J Peters Christian J CJ Wong Xiu Ming XM Cheng Tong T Jan Yuh Nung YN Jan Lily Yeh LY Yang Huanghe H
eLife 20140630
TMEM16A forms calcium-activated chloride channels (CaCCs) that regulate physiological processes such as the secretions of airway epithelia and exocrine glands, the contraction of smooth muscles, and the excitability of neurons. Notwithstanding intense interest in the mechanism behind TMEM16A-CaCC calcium-dependent gating, comprehensive surveys to identify and characterize potential calcium sensors of this channel are still lacking. By aligning distantly related calcium-activated ion channels in ...[more]