Ontology highlight
ABSTRACT:
SUBMITTER: Nam SJ
PROVIDER: S-EPMC4112586 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Nam Sang-Jip SJ Kauffman Christopher A CA Paul Lauren A LA Jensen Paul R PR Fenical William W
Organic letters 20131023 21
The isolation and structure elucidation of a new meroterpenoid, actinoranone (1), produced by a marine bacterium closely related to the genus Streptomyces is reported. Actinoranone is composed of an unprecedented dihydronaphthalenone polyketide linked to a bicyclic diterpenoid. The stereochemistry of 1 was defined by application of the advanced Mosher's method and by interpretation of spectroscopic data. Actinoranone (1) is significantly cytotoxic to HCT-116 human colon cancer cells with an LD50 ...[more]