Dataset Information

Job strain as a risk factor for type 2 diabetes: a pooled analysis of 124,808 men and women.

ABSTRACT:

Objective

The status of psychosocial stress at work as a risk factor for type 2 diabetes is unclear because existing evidence is based on small studies and is subject to confounding by lifestyle factors, such as obesity and physical inactivity. This collaborative study examined whether stress at work, defined as "job strain," is associated with incident type 2 diabetes independent of lifestyle factors.

Research design and methods

We extracted individual-level data for 124,808 diabetes-free adults from 13 European cohort studies participating in the IPD-Work Consortium. We measured job strain with baseline questionnaires. Incident type 2 diabetes at follow-up was ascertained using national health registers, clinical screening, and self-reports. We analyzed data for each study using Cox regression and pooled the study-specific estimates in fixed-effect meta-analyses.

Results

There were 3,703 cases of incident diabetes during a mean follow-up of 10.3 years. After adjustment for age, sex, and socioeconomic status (SES), the hazard ratio (HR) for job strain compared with no job strain was 1.15 (95% CI 1.06-1.25) with no difference between men and women (1.19 [1.06-1.34] and 1.13 [1.00-1.28], respectively). In stratified analyses, job strain was associated with an increased risk of diabetes among those with healthy and unhealthy lifestyle habits. In a multivariable model adjusted for age, sex, SES, and lifestyle habits, the HR was 1.11 (1.00-1.23).

Conclusions

Findings from a large pan-European dataset suggest that job strain is a risk factor for type 2 diabetes in men and women independent of lifestyle factors.

SUBMITTER: Nyberg ST

PROVIDER: S-EPMC4113178 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Job strain as a risk factor for type 2 diabetes: a pooled analysis of 124,808 men and women.

Nyberg Solja T ST Fransson Eleonor I EI Heikkilä Katriina K Ahola Kirsi K Alfredsson Lars L Bjorner Jakob B JB Borritz Marianne M Burr Hermann H Dragano Nico N Goldberg Marcel M Hamer Mark M Jokela Markus M Knutsson Anders A Koskenvuo Markku M Koskinen Aki A Kouvonen Anne A Leineweber Constanze C Madsen Ida E H IE Magnusson Hanson Linda L LL Marmot Michael G MG Nielsen Martin L ML Nordin Maria M Oksanen Tuula T Pejtersen Jan H JH Pentti Jaana J Rugulies Reiner R Salo Paula P Siegrist Johannes J Steptoe Andrew A Suominen Sakari S Theorell Töres T Väänänen Ari A Vahtera Jussi J Virtanen Marianna M Westerholm Peter J M PJ Westerlund Hugo H Zins Marie M Batty G David GD Brunner Eric J EJ Ferrie Jane E JE Singh-Manoux Archana A Kivimäki Mika M

Diabetes care 20140801 8

<h4>Objective</h4>The status of psychosocial stress at work as a risk factor for type 2 diabetes is unclear because existing evidence is based on small studies and is subject to confounding by lifestyle factors, such as obesity and physical inactivity. This collaborative study examined whether stress at work, defined as "job strain," is associated with incident type 2 diabetes independent of lifestyle factors.<h4>Research design and methods</h4>We extracted individual-level data for 124,808 diab ...[more]

PMID: 25061139

Similar Datasets

Project description:BackgroundThe diagnosis of type 2 diabetes (T2D) in younger adults, an increasingly common public health issue, is associated with a higher risk of cardiovascular complications and mortality, which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AimTo investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.MethodsA pooled dataset was used, comprised of data from five previous studies of adults with T2D, including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years. Anthropometric and blood biomarker measurements included body weight, body mass index (BMI), waist circumference, body fat percentage, glycaemic control (HbA1c), lipid profile and blood pressure. Univariable and multivariable linear regression models, adjusted for diabetes duration, sex, ethnicity and smoking status, were used to investigate the association between age at diagnosis and each cardiovascular risk factor.ResultsA higher proportion of participants diagnosed with T2D under the age of 40 were female, current smokers and treated with glucose-lowering medications, compared to participants diagnosed later in life. Participants diagnosed with T2D under the age of 40 also had higher body weight, BMI, waist circumference and body fat percentage, in addition to a more adverse lipid profile, compared to participants diagnosed at an older age. Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight [95% confidence interval (CI): 0.52-0.82 kg], 0.18 kg/m2 higher BMI (95%CI: 0.10-0.25) and 0.32 cm higher waist circumference (95%CI: 0.14-0.49), after adjustment for duration of diabetes and other confounders. Younger age at diagnosis was also significantly associated with higher HbA1c, total cholesterol, low-density lipoprotein cholesterol and triglycerides.ConclusionThe diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile, compared to those diagnosed later in life.

Dataset Information

Job strain as a risk factor for type 2 diabetes: a pooled analysis of 124,808 men and women.

Objective

Research design and methods

Results

Conclusions

Publications

Job strain as a risk factor for type 2 diabetes: a pooled analysis of 124,808 men and women.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets