Ontology highlight
ABSTRACT:
SUBMITTER: Mich JK
PROVIDER: S-EPMC4113417 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Mich John K JK Payumo Alexander Y AY Rack Paul G PG Chen James K JK
PloS one 20140728 7
The Hedgehog (Hh) pathway is essential for embryonic development and tissue regeneration, and its dysregulation can lead to birth defects and tumorigenesis. Understanding how this signaling mechanism contributes to these processes would benefit from an ability to visualize Hedgehog pathway activity in live organisms, in real time, and with single-cell resolution. We report here the generation of transgenic zebrafish lines that express nuclear-localized mCherry fluorescent protein in a Gli transc ...[more]