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Nocapyrones: ?- and ?-pyrones from a marine-derived Nocardiopsis sp.


ABSTRACT: One new ?-pyrone (nocapyrone R (1)), and three known ?-pyrones (nocapyrones B, H and L (2-4)) were isolated from the culture extract of a Nocardiopsis strain collected from marine sediment. Structures of these compounds were determined on the basis of spectroscopic data including NMR and MS. ?-Pyrones 2-4 were found to induce adiponectin production in murine ST-13 preadipocyte cells but the ?-pyrone 1 had no activity. The absolute configuration of the anteiso-methyl branching in 4 was determined by HPLC comparison of a degraded product of 4 with standard samples as a 2:3 enantiomeric mixture of (R)- and (S)-isomers.

SUBMITTER: Kim Y 

PROVIDER: S-EPMC4113818 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature

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