Unknown

Dataset Information

0

Nocapyrones: ?- and ?-pyrones from a marine-derived Nocardiopsis sp.


ABSTRACT: One new ?-pyrone (nocapyrone R (1)), and three known ?-pyrones (nocapyrones B, H and L (2-4)) were isolated from the culture extract of a Nocardiopsis strain collected from marine sediment. Structures of these compounds were determined on the basis of spectroscopic data including NMR and MS. ?-Pyrones 2-4 were found to induce adiponectin production in murine ST-13 preadipocyte cells but the ?-pyrone 1 had no activity. The absolute configuration of the anteiso-methyl branching in 4 was determined by HPLC comparison of a degraded product of 4 with standard samples as a 2:3 enantiomeric mixture of (R)- and (S)-isomers.

SUBMITTER: Kim Y 

PROVIDER: S-EPMC4113818 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature

altmetric image

Publications

Nocapyrones: α- and γ-pyrones from a marine-derived Nocardiopsis sp.

Kim Youngju Y   Ogura Hiromu H   Akasaka Kazuaki K   Oikawa Tsutomu T   Matsuura Nobuyasu N   Imada Chiaki C   Yasuda Hisato H   Igarashi Yasuhiro Y  

Marine drugs 20140708 7


One new α-pyrone (nocapyrone R (1)), and three known γ-pyrones (nocapyrones B, H and L (2-4)) were isolated from the culture extract of a Nocardiopsis strain collected from marine sediment. Structures of these compounds were determined on the basis of spectroscopic data including NMR and MS. γ-Pyrones 2-4 were found to induce adiponectin production in murine ST-13 preadipocyte cells but the α-pyrone 1 had no activity. The absolute configuration of the anteiso-methyl branching in 4 was determined  ...[more]

Similar Datasets

| S-EPMC4110758 | biostudies-literature
| S-EPMC5577594 | biostudies-literature
| S-EPMC3350997 | biostudies-literature
| S-EPMC6627118 | biostudies-literature
| S-EPMC6174345 | biostudies-literature
| S-EPMC6223224 | biostudies-literature
| S-EPMC9029069 | biostudies-literature
| S-EPMC4731795 | biostudies-literature
| S-EPMC2901511 | biostudies-literature
| S-EPMC7080967 | biostudies-literature