Ontology highlight
ABSTRACT:
SUBMITTER: Li XJ
PROVIDER: S-EPMC4114963 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Li Xiao-jun XJ Hayward Clive C Fong Pui-Yee PY Dominguez Michel M Hunsucker Stephen W SW Lee Lik Wee LW McLean Matthew M Law Scott S Butler Heather H Schirm Michael M Gingras Olivier O Lamontagne Julie J Allard Rene R Chelsky Daniel D Price Nathan D ND Lam Stephen S Massion Pierre P PP Pass Harvey H Rom William N WN Vachani Anil A Fang Kenneth C KC Hood Leroy L Kearney Paul P
Science translational medicine 20131001 207
Each year, millions of pulmonary nodules are discovered by computed tomography and subsequently biopsied. Because most of these nodules are benign, many patients undergo unnecessary and costly invasive procedures. We present a 13-protein blood-based classifier that differentiates malignant and benign nodules with high confidence, thereby providing a diagnostic tool to avoid invasive biopsy on benign nodules. Using a systems biology strategy, we identified 371 protein candidates and developed a m ...[more]