Ontology highlight
ABSTRACT:
SUBMITTER: Pellegrino R
PROVIDER: S-EPMC4115286 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Hepatology (Baltimore, Md.) 20140327 5
<h4>Unlabelled</h4>Mouse Double Minute homolog 4 (MDM4) gene up-regulation often occurs in human hepatocellular carcinoma (HCC), but the molecular mechanisms responsible for its induction remain poorly understood. Here we investigated the role of the phosphoinositide-3-kinase/v-akt murine thymoma viral oncogene homolog/mammalian target of rapamycin (PI3K/AKT/mTOR) axis in the regulation of MDM4 levels in HCC. The activity of MDM4 and the PI3K/AKT/mTOR pathway was modulated in human HCC cell line ...[more]