Ontology highlight
ABSTRACT:
SUBMITTER: Lohse MB
PROVIDER: S-EPMC4115540 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Lohse Matthew B MB Rosenberg Oren S OS Cox Jeffery S JS Stroud Robert M RM Finer-Moore Janet S JS Johnson Alexander D AD
Proceedings of the National Academy of Sciences of the United States of America 20140703 29
WOPR-domain proteins are found throughout the fungal kingdom where they function as master regulators of cell morphology and pathogenesis. Genetic and biochemical experiments previously demonstrated that these proteins bind to specific DNA sequences and thereby regulate transcription. However, their primary sequence showed no relationship to any known DNA-binding domain, and the basis for their ability to recognize DNA sequences remained unknown. Here, we describe the 2.6-Å crystal structure of ...[more]